Chronic active hepatitis associated with trazodone therapy
Article Abstract:
A 75-year-old Asian woman developed chronic hepatitis after treatment with trazodone. Trazodone is an antidepressant that has been used since the early 1980s in the US. The patient was admitted to the hospital with jaundice. She had started experiencing nausea and appetite loss approximately eight months before she developed jaundice. The onset of these symptoms coincided with the beginning of treatment with trazodone for depression. She had no history of alcohol or intravenous drug use, and she had no previous history of jaundice. Blood tests for hepatitis A virus and hepatitis C virus were negative. Antibodies were detected against certain types of hepatitis B antigens. A liver biopsy revealed chronic active hepatitis. Her condition improved after she stopped taking the drug. At least three other cases of trazodone-induced liver damage have been reported in the medical literature.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1993
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Hepatitis G virus infection: a work in progress
Article Abstract:
While much is known about the prevalence and structure of the hepatitis G virus (HGV), no condition has been specifically linked to this virus. It is also unclear what danger HGV poses to the blood supply and whether it can be reliably identified. Studies have shown that many patients with hepatitis C virus (HCV) infections also have HGV infections and respond to interferon therapy. Patients with both HCV and HGV infections do not appear to have more severe liver injury than those with only an HCV infection. Patients acquire HGV infections by a blood to blood route, frequently through blood transfusions.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1996
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Outcomes of chronic infection with hepatitis B virus
Article Abstract:
About 70% of people infected with the hepatitis B virus will clear the virus from their body within 10 years. In a study of 1,536 Alaska natives who were infected and never treated, only eight died of liver failure and 36 developed liver cancer.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 2001
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