Clindamycin and ibuprofen effects on chlamydia salpingitis in mice

Article Abstract:

Pelvic inflammatory disease (PID), the inflammation and infection of the uterus and fallopian tubes within the female pelvis, can be caused by bacteria. Salpingitis is the inflammation of the fallopian tubes, which lead from the ovaries to the uterus. When these tubes are seriously damaged, infertility results. Thirteen percent of patients diagnosed with PID will become infertile due to salpingitis. Treatment of PID focuses on eliminating the infection with antibiotics and reducing the inflammation with anti-inflammatory drugs. The Centers for Disease Control advises broad spectrum antibiotic drug therapy for the treatment of salpingitis. However, one of the recommended antibiotics, clindamycin-aminoglycoside may not be effective in treating Chlamydia trachomatis, a bacteria which is responsible for 30 percent of PID infections. Clindamycin and ibuprofen, a non steroidal anti-inflammatory drug (NSAID), were given to 64 mice infected with chlamydial salpingitis. The drugs were given separately (either clindamycin or ibuprofen), in combination or not at all. In the untreated group 66.7 percent of the mice had evidence of pelvic inflammation and 46.7 percent cultured positive for chlamydia. Results from all three groups of treated mice showed that 22.4 percent had pelvic inflammation and 10.2 percent cultured positive for the bacteria. Whether clindamycin and ibuprofen were given separately or in combination, they were equally effective in reducing the inflammation of the chlamydia infection in addition to reducing the presence of Chlamydia trachomatis in the genital tract.

Health aspects, Models, Evaluation, Drug therapy, Ibuprofen, Salpingitis, Clindamycin

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New opportunities for chlamydia prevention: applications of science to public health practice

Article Abstract:

Advances in the diagnosis and treatment of chlamydia, infertility-prevention legislation, and research endeavors may improve public health programs. Urine tests can detect the microorganism that causes chlamydia and may be widely used in nonclinical settings. Ninety-seven percent of all chlamydia cases can be cured with low-cost multidose antibiotics and single-dose therapies are available for noncompliant patients. Models of successful large-scale chlamydia screening and treatment programs focus on screening asymptomatic women to prevent reproductive tract complications and offer treatment to their male partners. The Preventive Health Amendments of 1992 provided funding for a variety of services to prevent infertility from chlamydia. Federal monies support research to evaluate urine tests for chlamydia, develop new methods to target services, and measure the effect of infertility prevention programs.

Prevention

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Clinical Features of Chlamydia trachomatis Rectal Infection by Serovar Among Homosexually Active Men

Article Abstract:

The authors investigated to determine if bacterial traces of Chlamydia trachomatis are similarly present in rectal infections as they are in cervical infections. They found that the correlation is present between rectal infection and the indicators for C. trachomatis.

Infection, Rectum

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