Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1
Article Abstract:
Women with ovarian cancer who have a mutation in the BRCA1 gene appear to have a better prognosis than those who do not. The BRCA1 gene has been implicated in hereditary breast and ovarian cancer. Researchers followed 53 women with ovarian cancer and a BRCA1 mutation. Forty-three women had advanced ovarian cancer but their median survival rate was 77 months, compared to 29 months in a similar group of women with ovarian cancer who did not have a BRCA1 mutation. After a median of 71 months, 20 women had died, 4 were still alive and 27 had no evidence of cancer.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1996
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Prophylactic mastectomy -- the price of fear
Article Abstract:
Prophylactic mastectomy may be psychologically devastating and totally unnecessary. During this operation, women who do not have breast cancer but have a high risk of breast cancer have one or both breasts surgically removed. A 1998 study found that prophylactic mastectomy reduced the risk of developing breast cancer by 90%. In the 639 women who had the operation, only two subsequently died of breast cancer, whereas 20 would have died without the operation. However, many of the women may never have developed breast cancer anyway. Physicians should find other ways of preventing breast cancer in high-risk women.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
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