Clinical experience with phenytoin prophylaxis in severe preeclampsia

Article Abstract:

Preeclampsia is an abnormal condition occurring during pregnancy which is characterized by high blood pressure, swelling and protein in the urine. In severe cases eclampsia develops and the mother may experience convulsions, coma and death. Treatment is aimed at reducing high blood pressure and preventing seizures. Magnesium sulfate is the drug of choice used to prevent convulsions of preeclampsia. The mechanism of action of magnesium sulfate is not understood; it is not classified as an anticonvulsant drug and it has many side effects. In an effort to find an alternative, phenytoin (dilantin), a common anticonvulsant used in nonpregnant patients, was prescribed for 104 preeclamptic patients. Four different dosage regimes were investigated. The side effects encountered in a few patients on the high dose of phenytoin were low blood pressure, jerky movements, and change in consciousness. Alterations in dose, calculated by the patient's weight, relieved side effects. No seizures were experienced after appropriate dosages were established. Although this study was not a controlled trial, the use of phenytoin for the prevention of seizures in preeclamptic patients before and after delivery, appears to be a safe and effective alternative.

Drug therapy, Preeclampsia, Convulsions, Phenytoin

---

Impact of selective laser ablation of placental anastomoses on the cardiovascular pathology of the recipient twin in severe twin-twin transfusion syndrome

Article Abstract:

The impact of selective laser ablation on the cardiovascular pathology of the recipient twin in twin-twin transfusion syndrome is investigated. The selective laser ablation in severe twin-twin transfusion syndrome improves biventricular systolic function and also tends to improve diastolic function in the recipient twin.

Diagnosis, Risk factors, Fetofetal transfusion, Pregnancy, Complications of, Pregnancy complications, Clinical report

---

Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section

Article Abstract:

A single injection of carbetocin appears to be more effective in preventing post-partum bleeding than oxytocin in women who have a cesarean section. Post-partum bleeding often occurs because the uterus is weak, a condition called uterine atony.

Complications and side effects, Cesarean section, Uterine bleeding, Uterine hemorrhage, Oxytocin

Similar abstracts:

• Abstracts: Bridging the generation gap with professional courtesy. Doctors launch sticker campaign against smoking ads. Healing in the Afghan hills
• Abstracts: Decreased levels of polyunsaturated fatty acids in preeclampsia. Pregnancy increases cardiovascular toxicity to cocaine
• Abstracts: Anthropometric evaluation of children with chronic liver disease. Normal vitamin E status in sickle hemoglobinopathies in Colorado
• Abstracts: Obstetrics and malpractice: evidence on the performance of a selective no-fault system. Medical malpractice experience of physicians: predictable or haphazard?
• Abstracts: Significant decrease in congenital malformations in newborn infants of an unselected population of diabetic women

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.