Clinical judgement and sickle cell disease
Article Abstract:
Children with sickle cell anemia may not require hospital admission for the treatment of fever without any other serious complications. Sickle cell anemia is a genetic disorder characterized by sickle-shaped red blood cells. This disorder is especially common in developing countries in Africa that have limited medical equipment and supplies. A research study found that children with sickle cell anemia could be treated on an outpatient basis for episodes of fever with no other serious complications. Treatment on an outpatient basis reduces the cost of treatment significantly and is more convenient for patients and their families. The study also acknowledged the importance of a comprehensive educational program for the parents of sickle cell anemia patients. Another important factor for the care of these patients is a team of health care personnel who are familiar with the disease.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1993
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Pathogenesis and treatment of sickle cell disease
Article Abstract:
More research is needed to identify effective treatments for sickle cell anemia. This disease is caused by a mutation in the gene for the beta-globin subunit of hemoglobin. The mutation causes the hemoglobin to clump together when oxygen is removed, creating long fibers that cause the characteristic sickle shape. These cells block small blood capillaries, causing many of the complications. The only effective treatments are those that increase the level of hemoglobin F, which appears to inhibit hemoglobin clumping. Effective drugs include hydroxyurea and possibly butyric acid. Bone marrow transplantation may also be effective.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
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Sickle cell disease - new treatments, new questions
Article Abstract:
It is not clear whether the benefits of regular blood transfusions for sickle cell patients will outweigh the risks. A 1998 study found that the rate of stroke was significantly reduced in a group sickle cell patients who received regular blood transfusions. However, regular blood transfusion is not without risk. About one-third of the patients in the study refused or did not continue to accept blood transfusions. In addition, about 40% of sickle cell patients will never have a stroke even if they don't receive transfusions.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
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