Clinical significance of beta-2-glycoprotein I-dependent anticardiolipin antibodies in the reproductive autoimmune failure syndrome: correlation with conventional antiphospholipid antibody detection systems

Article Abstract:

The presence in the blood of beta2-glycoprotein I-dependent (beta2-GPI-dependent) anticardiolipin antibodies appears to provide a better marker for an autoimmune response that causes recurrent miscarriage, infertility, and endometriosis than the presence of other single varieties of anticardiolipin antibodies. However, the presence of several types of anticardiolipin antibody does appear to be associated with reproductive failure. Banked serum samples from 259 women with suspected reproductive autoimmune failure syndrome and 97 infertile women controls whose infertility was due to other causes were analyzed for seven different anticardiolipin antibodies, including beta2-GPI-dependent anticardiolipin antibody. No sample from the control group contained beta2-GPI-dependent anticardiolipin antibodies compared with 5.4% of the study group. No single anticardiolipin antibody served to discriminate between the groups, but two or more types of anticardiolipin antibodies were found among 5.0% of samples from women with suspected reproductive autoimmune failure syndrome versus none of the control group samples.

Causes of, Infertility, Female, Female infertility, Antiphospholipid antibodies

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Antithyroid antibodies and the association with non-organ-specific antibodies in recurrent pregnancy loss

Article Abstract:

Antibody abnormalities appear to play an insignificant role in habitual miscarriage, but it still may be helpful to measure antithyroid and non-organ specific antibodies in women at high risk for autoimmunity-associated pregnancy loss. Up to 50% of cases of habitual miscarriage, which is three or more consecutive, spontaneous losses, have no known cause. Non-organ-specific autoantibodies have been linked with habitual miscarriage, but it is not known whether this applies only to women with autoimmune diseases or to all women. Blood samples were analyzed from 45 women with habitual miscarriage and 100 healthy women and men who served as controls. Among the women with recurrent miscarriages, 31% tested positive for antithyroid antibodies compared with 19% of the controls. This difference was not statistically significant. Eleven percent of the women with recurrent miscarriages also tested positive for non-organ-specific antibodies.

Measurement

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Thyroid autoantibodies are not associated with recurrent pregnancy loss

Article Abstract:

Antibodies against the thyroid gland do not appear to be related to recurring miscarriages. Researchers measured autoantibodies against the thyroid in blood samples from 74 women with a history of recurrent miscarriage and 75 women with no such history. Thirty percent of the women with a history of miscarriage had the autoantibodies but so did 37% of the women with no history of miscarriage.

Health aspects

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