Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus

Article Abstract:

Patients with localized cancer of the esophagus treated with a combination of chemotherapy and radiation therapy may survive longer than those treated with radiation therapy alone. Of 121 patients with localized cancer of the esophagus, 61 were treated with a combination of chemotherapy and radiation therapy, and 60 were treated with radiation therapy alone. Thirty-six patients (59%) in the combination group died during the study, compared with 53 (88%) in the radiation therapy alone group. Patients treated with a combination of chemotherapy and radiation therapy survived an average of 12.5 months, compared with an average of 8.9 months for those treated with radiation therapy alone. Twenty percent of patients in the combination group experienced life-threatening side-effects, compared with three percent of those in the radiation alone group. Many patients with esophageal cancer survive less than 10 months after diagnosis, and only 10% survive five years.

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Chemoradiotherapy of Locally Advanced Esophageal Cancer

Article Abstract:

Chemotherapy combined with radiation therapy appears to be more effective in treating esophageal cancer. Researchers randomly assigned 129 patients with esophageal cancer to receive radiation therapy only or radiation plus chemotherapy. Five-year survival rates were 26% in the group that received combination therapy and 0% in the group that received radiation therapy alone. A greater percentage of the combination therapy group was cured of the disease. However, toxic side effects were more frequent in the combination therapy group.

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Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer

Article Abstract:

Giving patients with laryngeal cancer radiation treatment and chemotherapy with cisplatin may be more effective in preserving the larynx than radiation treatment alone or chemotherapy followed by radiation treatment, according to a study of 547 patients. However, survival rates were similar in the three groups who received one of these treatments. Those who had chemotherapy also had more side effects.

Laryngeal cancer, Cisplatin

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