Composite outcomes in randomized trials: greater precision but with greater uncertainty?
Article Abstract:
Some medical researchers who evaluate the effect of a treatment on composite outcomes may not be reporting these studies adequately, according to a review of 167 clinical trials covering 300,276 patients. Composite outcome means the researcher studies the effect of the treatment on more than one outcome. Many studies use death as the final outcome, but others also include other non-fatal endpoints.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Clinical trials -- multiple treatments, multiple end points, and multiple lessons
Article Abstract:
Some of the problems with conducting and reporting complicated clinical trials are reviewed. Clinical trials have become complicated because they often evaluate more than one treatment. These types of clinical trials are called factorial trials. Other clinical trials evaluate the effect of the treatment on more than one outcome.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Economic return of clinical trials performed under the pediatric exclusivity program
Article Abstract:
A cohort study of pediatric exclusivity programs are used to quantify the economic return to industry for completing pediatric exclusivity trials. The results have shown that the economic return for pediatric exclusivity is variable, as it can generate lucrative returns or produce more modest returns on investment.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A comparison of outcomes in men 11 years after heart-valve replacement with a mechanical valve or bioprosthesis
- Abstracts: Calif. cites finances in rejecting residents' hours limits. Florida mulls regulation of direct contracting. For-profit conversions spawn new sources of charity
- Abstracts: Copper disposition of the fetus and placenta in a patient with untreated Wilson's disease. Parathyroid hormone-related protein levels in maternal and cord blood
- Abstracts: Antibacterial treatment of gastric ulcers associated with Helicobacter pylori. A major outbreak of severe acute respiratory syndrome in Hong Kong
- Abstracts: Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infants