Contraction inhibition by beta-agonists progressively decreases before labor in the rat myometrium
Article Abstract:
Desensitization to drugs designed to prevent labor may increase with gestational age. Researchers treated uterine muscle strips from pregnant rats of various gestational ages with ritodrine and terbutaline, two labor-inhibiting drugs, to determine when and to what degree desensitization to these drugs occurs. Desensitization increased as gestational age increased and before labor began. Degree of muscle contraction inhibition increased with concentration of the drug. No difference in response to contraction inhibition between the two drugs could be discerned. Desensitization to labor-inhibiting drugs may occur once a certain concentration of the drugs is surpassed. The function of receptors for the drugs may decrease as gestational age increases.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia
Article Abstract:
The influence of reduced uteroplacental perfusion pressure on plasma leptin and placenta leptin receptor expression in rats that develop hypertension in the third trimester of pregnancy is determined. Reduced uteroplacental perfusion pressure reduces litter size, fetal and placental weights, and maternal plasma leptin levels and increases placental expression of leptin receptors.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2005
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Mechanisms of lipopolysaccharide-induced changes in effects of contractile agonists on pregnant rat myometrium
Article Abstract:
A study on Wistar rats is conducted to investigate the induced changes of lipopolysaccharide (LPS) in effects of contractile agonists on pregnant rat myometrium. LPS increases uterine contractility of pregnant rats through release of endogenous prostaglandins and the inhibition of sodium pump by LPS acts as an additional mechanism in the augmentation of uterine excitability.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2004
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