Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors
Article Abstract:
The authors injected an animal-modeled version of hemophilia B, also known as factor IX deficiency, into mice and dogs. No toxic effects occurred in the animals and factor IX was produced in the mice for more than 17 months, with a smaller amount produced in the dogs for eight months or more.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
Article Abstract:
The authors treated hemophilia B in five dogs using an adeno-virus vector for gene transfer. They transferred the missing factor IX and achiever long lasting results, with the disease staying in abeyance for more than 17 months, and with no or minimal adverse immune responses.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Coaxing coagulation with RNA and cell fragments
Article Abstract:
Two studies were conducted, which described findings that could lead to new approaches for the treatment of hemophilia. The study broadens the understanding of clot formation and also highlights another problem with this class of treatment strategies.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Detection of bacteremia in adults: consequences of culturing an inadequate volume of blood. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter: a randomized, controlled trial
- Abstracts: Pilot randomized controlled trial of Chinese herbal treatment for HIV-associated symptoms. Human herpesvirus 8 oral shedding in HIV-infected men with and without Kaposi Sarcoma
- Abstracts: Effect of starting age of physical activity on bone mass in the dominant arm of tennis and squash players. Epidemiology of osteoporotic ankle fractures in elderly persons in Finland
- Abstracts: Increase in age at onset of rheumatoid arthritis in Japan over a 30 year period. Polymorphic CAG repeats of the androgen receptor gene and rheumatoid arthritis
- Abstracts: Micronutrient profiles in HIV-1-infected heterosexual adults. Effects of weight loss and exercise on the distribution of lead and essential trace elements in rats with prior lead exposure