Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

Article Abstract:

Studies report that human neutrophils contain functionally active cyclin-dependent kinases (CDK) and that structurally diverse CDK inhibitors induce caspase-dependent apoptosis and override powerful anti-apoptosis signals from survival factors such as granulocyte-macrophage colony-stimulating factor. These results demonstrate previously unrecognized potential for treatment of inflammatory disorders.

Health aspects, Care and treatment, Inflammation

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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

Article Abstract:

Protection of small cell lung cancer (SCLC) cells by extracellular matrix proteins against apoptosis is discussed with consideration of drug resistance and a mechanism for SCLC growth in vivo. SCLC has been found to be surrounded by an extensive stroma of extracellular matrix at primary and metastatic sites.

United Kingdom, Scotland, Physiological aspects, Genetic aspects, Cell death, Growth, Cytochemistry, Cancer cells, Drug resistance, Extracellular matrix, Lung cancer, Proteomics

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Incapacitating the immune system in cystic fibrosis

Article Abstract:

Researchers have shown how the inflammatory response is disarmed in a series of events favoring persistent infection. Neutrophil biology has disclosed that Pseudomonas aeruginosa in the lungs of individuals with cystic fibrosis has disabled the phagocytes, which have turned against each other.

Pseudomonas aeruginosa, Cystic fibrosis, Phagocytes

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