Integration of the transabdominal technique into a ongoing chorionic villus sampling program
Article Abstract:
Chorionic villus sampling (CVS) is a method used to diagnose fetal well-being by removing a sample of fetal tissue through a small tube (catheter) for genetic testing. The procedure is performed early in pregnancy, during the first three months, in contrast with the more common method of prenatal diagnosis, amniocentesis, performed in the second three months of pregnancy. The most common CVS sampling technique, transcervical aspiration removes fetal tissue through the cervical opening of the uterus. Another CVS method samples fetal tissue through the abdomen, transabdominal aspiration. In both techniques ultrasound, the use of high frequency sound to visualize internal structures, is used to guide the catheter needle to the desired location. The fetal loss rate for transcervical CVS is slightly higher than for amniocentesis, although the difference is not considered to be significant. There have been no major maternal complications reported from the CVS method. Transcervical CVS was performed on 544 patients and the transabdominal technique on 325 patients. Fetal loss during the first 100 transcervical procedure was 2.7 percent; the more catheter insertions, the greater the chance of fetal loss. After the first 100 procedures only 11 percent of the patients needed an additional catheter insertion to obtain an adequate amount of fetal tissue. Fetal loss rate for the transabdominal CVS was 2.6 percent. Most of the patients (98 percent) having the transabdominal catheter insertion required only one attempt. The incorporation of the transabdominal method of CVS did not alter the rate of fetal loss in an already existing transcervical CVS program. Although the transabdominal method had a success rate of 99 percent, it will not completely replace the transcervical method. Transabdominal CVS will be most useful in patients with unusual positioning of the uterus or placenta in whom the transcervical method is contraindicated.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1989
User Contributions:
Comment about this article or add new information about this topic:
Incidence and outcome of chromosomal mosaicism found at the time of chorionic villus sampling
Article Abstract:
Finding mosaicism as a result of chorionic villi sampling does not appear to be associated with a high risk of genetic abnormalities in the baby. In mosaicism, some cells are normal while others contain abnormal chromosomes. Researchers reviewed the records of 11,200 women who had chorionic villi sampling. There were 140 cases of mosaicism. Of these, 130 cases were followed up. In 20% of these cases, amniocentesis or percutaneous umbilical cord blood sampling confirmed the mosaicism. However, all pregnancies that were not terminated ended in the birth of a normal newborn.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Cytogenetic results of chorionic villus sampling: high success rate and diagnostic accuracy in the United States collaborative study. part 2
- Abstracts: Single-center comparison of results of 1000 prenatal diagnoses with chorionic villus sampling and 1000 diagnoses with amniocentesis
- Abstracts: Interpretation of chorionic villus sampling laboratory results is just as reliable as amniocentesis. The inadequacy of the current correction for maternal weight in maternal serum alpha-fetoprotein interpretation
- Abstracts: "Recovery only" ST-segment depression and the predictive accuracy of the exercise test. Comparison of silent and symptomatic ischemia during exercise testing in men
- Abstracts: The placental transfer of mifepristone (RU 486) during the second trimester and its influence upon maternal and fetal steroid concentrations