Cytokine and adhesion molecule expression in the minor salivary glands of patients with Sjogren's syndrome and chronic sialoadenitis
Article Abstract:
Cytokine expression, signifying involvement of the immune system, may not differ much between Sjogren's syndrome (SS) and chronic sialoadenitis (CS). Both diseases are characterized by inflammation of the salivary glands, but the autoantibodies produced in SS are not produced in CS. Salivary gland biopsies of six SS patients, six CS patients, and five healthy volunteers revealed that high levels of cytokines were expressed in the epithelial cells of the salivary ducts in SS and CS, but only low levels occurred in normal ducts. In the SS samples, white blood cells tended to occur in clusters, but in CS samples, they were scattered throughout the gland. SS salivary glands had a higher percentage of NKI-L16/LFA-1 cells than did CS glands. These cells have a tendency to form clusters, which would explain the clustering of white blood cells in salivary glands that occurs in SS.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Lp(a) lipoprotein levels as a predictor of risk for thrombogenic events in patients with Behcet's disease
Article Abstract:
Monitoring blood levels of a fat-protein complex called Lp(a) lipoprotein (Lp(a)) may be helpful in predicting the development of blood clots in patients with Behcet's disease. Behcet's disease is an inflammatory disorder of the small blood vessels causing sores on the skin, eyes, genitals, in the mouth, and may involve the joints and central nervous system. Researchers analyzed blood samples from 33 patients with Behcet's disease and 30 healthy volunteers for Lp(a), cholesterol, and other lipoprotein levels. Lp(a) blood levels were nearly twice as high in the patients with Behcet's disease compared to the healthy volunteers. The Lp(a) blood levels of the 5 patients with Behcet's disease and abnormal blood clotting were twice as high as the rest of the patients with Behcet's disease.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Selectin adhesion molecules in Behcet's disease
Article Abstract:
Patients with Behcet's disease have elevated blood levels of selectin adhesion molecules. Behcet's disease is an inflammation of blood vessels that has no known cause. Selectins are molecules that allow cells to bind to other cells.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 2000
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