Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4(super +) hemangiocytes
Article Abstract:
A study demonstrates that the magnitude of cytokine-mediated release of stromal-derived factor 1 (SDF-1) from platelets and the recruitment of nonendothelial CXCR4(super +)VEGFR1(super +) hematopoietic progenitors, or hemangiocytes, constitute the major determinant of revascularization. Results indicate that hematopoietic cytokines, through graded deployment of SDF-1 from platelets, support mobilization and recruitment of the CXCR4(super +)VEGFR1(super +) hemangiocytes, whereas VEGFR1 is essential for their angiogenic competency for augmenting revascularization.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
Article Abstract:
Research presented concerns how vascular endothelial growth factor and its homolog, placental growth factor, stimulate angiogenesis, focusing on the signaling receptor for PIGF during angiogenesis. Findings suggest that PIFG deficiency hampered plasma extravasation, angiogenesis, and collateral growth during inflammation, wound healing, ischemia, and cancer.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Role of PLGF in the intra-and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
Article Abstract:
The role played by vascular endothelial growth factor (VEGF), placental growth factor (PGF), Flk1 receptor tyrosine kinase (RTK) is illustrated. The placental growth factor(PIGF) regulates inter- and intramolecular cross talk between the VEGF RTKs Flt1 and Flk1 is reported.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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