VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis

Article Abstract:

Vascular endothelial growth factor (VEGF) exerts crucial functions during pathological angiogenesis and normal physiology. Studies using hepatocyte-specific deletion of the Vegfa gene and hepatocyte-endothelial cell cocultures indicated that blockade of VGEF induced hepatic Epo by interfering with homeostatic VEGFR2-dependent paracrine signaling involving interactions between hepatocytes and endothelial cells. These data indicated that VEGF was a negative regulator of hepatic Epo synthesis and erythropoiesis.

Vascular endothelial growth factor, Erythropoietin

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Cytokine traps: multi-component, high-affinity blockers of cytokine action

Article Abstract:

This article describes novel 'cytokine traps' that block cytokines with high-affinity in vivo and in vitro. The traps are fusions between IgG constant region and the extracellular domains of two different cytokine receptor components, which mediate cytokine binding. Data indicate that the traps can be therapeutic agents for cytokine-mediated diseases.

United States, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Enzyme Inhibitors, Cytokines, Protein engineering, Cytokine receptors

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Angiopoietin-1 protects the adult vasculature against plasma leakage

Article Abstract:

Angiopoietin-1 prevented vascular leakage in mice when delivered in a viral vector to mice who had received vascular endothelial growth factor (VEGF) VEGF increases vascular permeability. This could be a useful treatment in conditions that cause edema and swelling.

Prevention, Blood vessels, Permeability

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