Detection by enzymatic amplification of bcr-abl mRNA in peripheral blood and bone marrow cells of patients with chronic myelogenous leukemia

Article Abstract:

In a form of leukemia, chronic myelogenous leukemia, approximately 90 percent of patients have a chromosomal anomaly called the Philadelphia chromosome, which is a genetic transfer of a small segment from chromosome 9 to chromosome 22. The precise point at which this break occurs results in different expressions of the disease. The current study examines the irregular production of an important gene messenger of the affected gene sites in cases of chronic myelogenous leukemia using a powerful new biochemical method. The product is messenger RNA, the material which carries the genetic signal for the synthesis of unique protein from the nucleus (the site of the genes) to the cytoplasm of the cell. The new detection method is sensitive, reliable and fast. Material for analysis can be drawn either from the veins or from bone marrow of the patient. Even following treatments which destroy the bone marrow, this messenger RNA can still be detected, indicating the presence of a small number of cells which continue to produce the tumor-related messenger RNA.

Research, Genetic aspects, Messenger RNA, Chromosome abnormalities, Blood diseases, Hematologic diseases, Leukemia research, Myeloblastic leukemia

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Correlation between interleukin-1 production and engraftment of transplanted bone marrow stem cells in patients with lethal immunodeficiencies

Article Abstract:

Monocytes, a particular type of white blood cells, are normally able to produce an important cell protective compound, interleukin-1 (IL-1) when stimulated in tissue culture by any of several agents, including bacterial poison (endotoxin). This study examined the ability of monocytes taken from a group of patients suffering from various congenital immune deficient conditions to produce interleukin, and found it to be variable. Monocytes from two patients were not able to be stimulated to produce IL-1, perhaps indicating an intrinsic problem with the mechanism of IL- or the presence of some unknown process which prevents the production of this compound. Several of the patients received transplants; the inability to produce IL-1 was proportional to the extent of graft failure. The inability of monocytes in these patients to produce IL-1 may directly relate to the inability of some patients to accept and maintain grafts, and to develop other forms of white blood cells such as T cells.

Physiological aspects, Immunological deficiency syndromes, Immunologic deficiency syndromes, Bone marrow transplantation, Monocytes, Transplantation of organs, tissues, etc., Organ transplantation, Tissue transplantation, Transplantation, Interleukin-1

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Hematopoietic bone marrow recovery after radiation therapy: MRI evaluation

Article Abstract:

Magnetic resonance imaging (MRI) is a method of examining the organs and internal structures of the body in fine detail without the use of X-rays or potentially hazardous materials. MRI is able to detect the change in bone marrow that occurs following radiotherapy for a variety of cancers (including Hodgkin's lymphoma, uterine, cervical, ovarian dysgerminoma, testicular and non-Hodgkin's lymphoma). Complete bone marrow recovery was seen only in patients who received less than a threshold level of radiotherapy. Characteristic changes were seen to occur between six months and one year following treatment, and were found in most patients five to six years after treatment. Complete recovery only occurred in patients who had received radiation therapy 10 to 23 years prior to the time of observation.

Evaluation, Measurement, Complications and side effects, Radiotherapy, Magnetic resonance imaging, Hematopoietic system

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