bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma
Article Abstract:
Large-cell lymphomas are newly-formed, often abnormal, tissue growths in the lymphatic system, and are members of a group of advanced, aggressive B-cell neoplasms, tumors which are often cancerous. Half the patients with large cell or mixed large- and small-cell lymphomas either go into remission or are totally cured by combined chemotherapy. Why the others do not respond has not been well understood. The role of genetic changes in B-cells, especially the 2p chromosome (bcl-2), was associated with recurrent lymphomas and a poor prognosis for patients suffering from this type of cancer in spite of multi-drug chemotherapy. Different defects in the chromosome were associated with different responses to therapy. The authors conclude that in large-cell lymphoma, multiple recurrent defects in the chromosome may be important is determining patient outcome.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1989
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Comparison of a second-generation combination chemotherapeutic regimen (m-BACOD) with a standard regimen (CHOP) for advanced diffuse non-Hodgkin's lymphoma
Article Abstract:
A standard chemotherapy regimen may be more effective and safe than an aggressive chemotherapy regimen for the treatment of advanced non-Hodgkin's lymphoma. Among 325 patients with advanced non-Hodgkin's lymphoma, 174 were treated with a standard chemotherapy regimen of cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) and 151 were treated with an aggressive regimen of bleomycin, doxorubicin, cyclophosphamide, vincristine, dexamethasone, methotrexate and leucovorin (m-BACOD). After an average of four years, the length of time until treatment failure and disease-free survival were similar for patients in both treatment groups. Patients in the m-BACOD group were more likely than those in the CHOP group to develop life-threatening side effects such as infections and complications affecting the blood and lungs.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1992
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Infection and lymphoma
Article Abstract:
The link between infectious mononucleosis and a type of cancer called Hodgkin's disease supports the idea that the Epstein-Barr virus may cause Hodgkin's disease. Some researchers have found the Epstein-Barr virus in Reed-Sternberg cells, a type of cancerous cell found in patients with Hodgkin's disease. People who have mononucleosis should have regular medical checkups so doctors can diagnose Hodgkin's disease in its early stages when it is more easily treated.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
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