Diabetic retinopathy mechanism probed

Article Abstract:

An international team of researchers resurrected a theory to explain the mechanism underlying how chronic hyperglycemia in diabetes causes the microvascular complications that lead to diabetic retinopathy and other tissue problems. Scientists reported that a primary cause of microvascular complications is chemically reactive, tissue-damaging free radicals and other chemical changes resulting from the increased transfer of electrons and protons.

Science & research, Research, Complications and side effects, Diabetic retinopathy, Hyperglycemia

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Moderators of treatment outcomes: Clinical ,Research and policy importance

Article Abstract:

A brief review of the logical basis of randomized clinical trials (RCT) methodology is presented to show how central moderators of treatment are to RCTs. Several approaches to identify moderators are discussed, and the advantages and potential objections to the proposed approaches are considered.

United States, Product standards, safety, & recalls, Standards, Clinical trials

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