Diagnostic utility of immune-complex-dissociated p24 antigen detection in perinatally acquired HIV-1 infection in Rwanda
Article Abstract:
An acid treatment form of the p24 antigen test for the presence of HIV may be a simple and less expensive way of detecting HIV in infants in developing countries. Researchers tested blood samples of infants born to Rwandan women infected with HIV type 1 with the test, in which blood samples are treated with acid. The acid test could not detect HIV in all infected infants, probably because the mother's antibodies were still present in the infants' blood. The test detected HIV in 17.6% of six-week-old infants and in 33.3% of three-month-olds. Where the test did detect HIV, it predicted that HIV disease would occur soon and be severe. All of the infants that tested HIV positive died before their third birthdays.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Identification of a site for a cohort study on natural history of HIV infection in Ethiopia
Article Abstract:
Researchers working for the Ethiopian-Netherlands AIDS Research Project (ENARP) have chosen a potential group of volunteers to participate in a study of the natural history of HIV infection in Africa. There are few such studies in developing countries and results from industrialized areas can not always be applied to developing countries. The group was chosen from residents of a sugar estate near Addis Ababa in Ethiopia. About 3% of the 957 adults tested positive for HIV. Of a smaller group of male factory workers, 9% tested positive for HIV.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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Detection of HIV-1 infection with a green fluorescent protein reporter system
Article Abstract:
A cell line that contains a fluorescent protein can be used to detect HIV in various tissues. The protein occurs naturally in a specific jellyfish and emits a green wavelength. Researchers introduced the protein into a cell line which was then infected with HIV. As the virus begins to reproduce, it causes the protein to fluoresce. This can be detected by fluorescence microscopy and is a simple and convenient method for detecting HIV.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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