Disseminated intravascular coagulation after factor IX complex resolved using purified factor IX concentrate

Article Abstract:

Disseminated intravascular coagulation is a process in which the proteins normally used by blood to clot are rendered useless, resulting in an increased risk of bleeding. Hemophilia is an inherited disease of males in which certain blood clotting proteins are missing, leaving individuals with this disease at risk of bleeding complications. Treatment of bleeding episodes of hemophilia includes transfusing patients with these clotting proteins, in a form known as factor IX complex. Some of the components of factor IX complex can cause disseminated intravascular coagulation. A 41-year-old man with hemophilia who came to the hospital with a hemorrhage in his brain was treated with conventional preparations of factor IX complex and drainage of the blood. He showed signs of improvement, but after several days of treatment with factor IX complex, his blood tests showed him to be suffering disseminated intravascular coagulation, which could have worsened the bleeding in his brain. He was then given a new, purified form of factor IX complex, and the disseminated intravascular coagulation stopped. His condition improved steadily, and he was discharged. At least in this one patient, the newer, purified factor IX complex appeared to have been safe, even in the face of pre-existing disseminated intravascular coagulation. (Consumer Summary produced by Reliance Medical Information, Inc.)

Causes of, Complications and side effects, Drug therapy, Brain, Brain hemorrhage, Hemophilia, Disseminated intravascular coagulation, Prothrombin complex concentrate, Factor IX (Blood coagulation)

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Infections Acquired during Cardiopulmonary Resuscitation: Estimating the Risk and Defining Strategies for Prevention

Article Abstract:

There appears to be an extremely low risk of acquiring HIV from cardiopulmonary resuscitation (CPR). Researchers reviewed the medical literature back to 1965 and found only three cases of HIV infection transmitted during CPR. In each case, however, the person performing CPR was exposed to the patient's blood. This is a much more likely cause of transmission because there are no reports of HIV being transmitted via saliva. Proper infection control procedures can reduce the risk even further.

Health aspects, Risk factors, HIV infection, HIV infections, HIV (Viruses), HIV, Disease transmission, CPR (First aid), Cardiopulmonary resuscitation

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