Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia/intrauterine growth restrictions

Article Abstract:

A study to compare trophoblast invasion into the spiral arteries in pregnancies with maternal anemia or early-onset preeclampsia/intrauterine growth restriction is conducted and the findings were related to trophoblast apoptosis. The results reveal that trophoblast invasion into the placental bed in early-onset preeclampsia/intrauterine growth restriction is limited by increased apoptosis, resulting in a narrower spiral arteries.

Anemia, Pregnant women

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Heparin and aspirin attenuate placental apoptosis in vitro: Implications for early pregnancy failure

Article Abstract:

The roles of heparin and aspirin, which might attenuate miscarriage by inhibiting aberrant coagulation or by modulating trophoblast apoptosis, in trophoblast apoptosis in vitro are assessed. Heparin and aspirin modulate trophoblast apoptosis suggesting a direct impact on trophoblast biology provide an additional mechanism to explain the clinical benefits of heparin and aspirin on recurrent pregnancy loss.

United States, Science & research, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Aspirin, Aspirin Combinations, Research, Causes of, Complications and side effects, Miscarriage, Heparin (Medication)

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Apoptosis and its role in the trophoblast

Article Abstract:

Apoptosis is described in both types of trophoblast and the importance of this cascade for the normal function of the trophoblast is presented. Recent findings on trophoblast apoptosis in normal and pathologic pregnancies are summarized.

Trophoblast, Trophoblasts

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