Narrow QRS ventricular tachycardia

Article Abstract:

Abnormal heart rhythms can be generally classified by the chamber of heart that gives rise to them. Those which arise in the ventricles (the lower chambers) are ventricular tachycardias (rapid rhythms), and those that arise in the upper chambers of the heart are referred to as supraventricular tachycardias. Ordinarily, ventricular tachycardias have characteristic electrocardiogram changes, known as wide QRS complexes, while supraventricular tachycardias give narrow QRS complexes. Rare cases of narrow QRS ventricular tachycardia have been reported. A group of 106 patients who were followed by a specialized arrhythmia service and who were known to have ventricular tachycardia had their electrocardiograms reviewed using the criteria for narrow QRS ventricular tachycardia. Five of these patients had electrocardiograph readings that indicated narrow QRS ventricular tachycardia. These five had specialized studies which proved that the narrow QRS tachycardias were indeed ventricular in origin, suggesting that this entity is not as rare as is generally believed. Since the treatment for the two tachycardias is quite different, ventricular tachycardia should be considered as a possible diagnosis for patients with a narrow complex tachycardia and who do not respond to conventional therapy for supraventricular tachycardia. (Consumer Summary produced by Reliance Medical Information, Inc.)

Evaluation, Diagnosis, Electrocardiogram, Electrocardiography, Supraventricular tachycardia, Ventricular tachycardia

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Increased plasma rifabutin levels with concomitant fluconazole therapy in HIV-infected patients

Article Abstract:

Fluconazole may prevent the breakdown of rifabutin in the bloodstream thereby increasing the blood concentrations and possibly the effectiveness of rifabutin and one of its products, LM565, in patients with human immunodeficiency virus (HIV) infections. Researchers analyzed the blood levels of fluconazole, rifabutin, and LM565 in 12 patients with HIV who took fluconazole for two weeks, fluconazole plus rifabutin for two weeks, followed by two weeks of rifabutin therapy alone. Rifabutin blood levels increased by 82% and LM565 blood levels increased by 216% when taken with fluconazole. Rifabutin urine levels also increased when taken with fluconazole. Blood and urine levels of fluconazole did not change. None of the patients developed any additional disease symptoms or unusual laboratory findings during the study period.

Physiological aspects, HIV patients, Antitubercular agents, Fluconazole

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