Down syndrome and neural tube defect screening: the value of using gestational age by ultrasonography

Article Abstract:

Down syndrome detection rates may be more accurate when gestational age of the infant is determined by ultrasound than by date of last menstrual period (LMP). Researchers compared initial and revised Down syndrome detection rates for over 24,000 women, and gestational age and testing results for 24 Down syndrome pregnancies. Initial and revised screening rates were lower and detection rates were higher and more accurate for pregnancies dated with ultrasound measurement of fetal head diameter. A benefit to use of ultrasound to determine gestational age is that fewer amniocentesis samples need to be taken.

Gestational age

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Role of ultrasound for Down syndrome screening in advanced maternal age

Article Abstract:

Combining blood tests with ultrasound scans for fetal anatomic abnormalities can improve the prenatal diagnosis of Down syndrome in women 35 years old or older. The combined screen detects 97% of fetuses with Down syndrome with a 22% false-positive test.

Evaluation, Prenatal diagnosis

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Down syndrome births in the United States from 1989 to 2001

Article Abstract:

Investigating trends in Down syndrome live births in the US from 1989 to 2001 using birth certificate data. Down syndrome live births declined in the US despite an expected increase caused by delayed or extended childbearing.

United States, Causes of, Pregnancy, Protracted, Post-term pregnancy

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