Early detection of undiagnosed non-insulin-dependent diabetes mellitus
Article Abstract:
Measuring blood levels of glycosylated hemoglobin shows promise as a means of detecting non-insulin-dependent diabetes. Measuring glycosylated hemoglobin is simpler and more convenient than current diagnostic tests, which measure blood glucose. Many adults have undiagnosed diabetes. Increasing the number of diabetics identified early and treated could markedly reduce the development of diabetes-related complications in those persons. Some problems remain with the glycosylated hemoglobin test: setting the diagnostic threshold, standardizing laboratory analysis techniques, and reconciling disagreements with results of current diagnostic tests, although discrepancies could be a weakness of current tests.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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Relationship Between Fasting Plasma Glucose and Glycosylated Hemoglobin: Potential for False-Positive Diagnoses of Type 2 Diabetes Using New Diagnostic Criteria
Article Abstract:
People should not be diagnosed with type 2 diabetes unless their fasting blood sugar is 126 or greater and their glycosylated hemoglobin level is greater than normal. High levels of glycosylated hemoglobin are a more precise measurement of abnormal sugar metabolism. Some doctors propose lowering the threshold for a diagnosis of diabetes from a fasting blood sugar of 140 to 126. Researchers analyzed glycosylated hemoglobin levels in people participating in two large population studies. About 60% of the people diagnosed as diabetics under the new proposal had normal glycosylated hemoglobin levels. These people could be falsely diagnosed with diabetes.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
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A clinical approach for the diagnosis of diabetes mellitus: an analysis using glycosylated hemoglobin levels
Article Abstract:
Glycosylated hemoglobin levels appears to be a promising approach to diagnosing diabetes mellitus. Measuring glycosylated hemoglobin measurement offers several advantages over measuring fasting glucose and the oral glucose tolerance test. Glycosylated hemoglobin level is already used to determine whether to treat and the effectiveness of treatment. An analysis of the correlation in 8,984 persons of glycosylated hemoglobin level with fasting blood glucose and glucose level two hours after a glucose drink revealed that all persons likely to have diabetes could be identified by using a threshold of 7% for glycosylated hemoglobin.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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