Low-Density Lipoprotein Size, Pravastatin Treatment, and Coronary Events
Article Abstract:
Large particles of low-density lipoprotein (LDL) appear to increase the risk of heart attack or unstable angina compared to small LDL particles. However, treatment with cholesterol-lowering drugs may eliminate this risk, regardless of the size of the patient's LDL particles.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
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A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction
Article Abstract:
People with elevated blood levels of fats called triglycerides may have a higher risk of heart attack than those who do not. Researchers with the Physician Health Study found that in the 14,916 men participating, those who had a heart attack had smaller low-density lipoprotein (LDL) particles and higher triglyceride levels. The risk associated with small LDL particles disappeared when the data were adjusted for other risk factors. However, the risk of elevated triglyceride levels remained, especially if the men also had elevated cholesterol levels.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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Effect of Pravastatin on Cardiovascular Events in Older Patients with Myocardial Infarction and Cholesterol Levels in the Average Range
Article Abstract:
Pravastatin appears to reduce the risk of heart attacks and stroke in older patients with average levels of blood cholesterol and a previous heart attack. Pravastatin is a cholesterol-lowering drug. Researchers treated 1,283 elderly patients, with average cholesterol levels of 240 mg/dL, with either pravastatin or a placebo. In five years of study, 19.7% of patients taking pravastatin, and 28.1% of patients taking a placebo, had a heart attack or other major coronary event. Pravastatin treatment lowered the risk of heart attack by 45% and the stroke risk by 40% in this group of elderly patients.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1998
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