Effect of whole-body hyperthermia on AIDS patients with Kaposi's sarcoma: a pilot study
Article Abstract:
Elevating the body temperature of HIV-infected people with Kaposi's sarcoma (KS) appears to be safe and may cause a regression of KS and a decrease in the amount of HIV in blood plasma. Six men with AIDS and KS underwent whole-body hyperthermia (WBHT), in which their core body temperature was raised to either 40 or 42 degrees Celsius for one hour. Researchers used heat blankets in combination with a system that pumped blood to and from the person's body to heat it while controlling its chemistry and fluid balance. No serious side effects occurred in the patients as a result of the treatment. Regression of KS occurred immediately after WBHT at both temperatures, but this effect was not observable 1 week after treatment. Plasma HIV RNA levels decreased after the 42-degree WBHT treatment, but this effect was also not maintained after 1 week. In the 40-degree WBHT group, CD4 immune cell numbers were reduced throughout an 8-week follow-up period.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Developing quality review criteria from standards of care for HIV disease: a framework
Article Abstract:
Medical personnel in managed care settings may use a framework based on established standards of HIV care to develop HIV quality review criteria. Criteria to evaluate the quality of care must allow for reasonable differences in HIV treatment among medical practices. Local standards and patient and provider preferences are major factors in defining appropriate care. Quality review criteria must differentiate medically necessary care from inappropriate care. Medically necessary HIV care includes antiretroviral therapy for AIDS patients, screening for dormant infections or unrecognized diseases, and drug therapy to prevent infections in patients with end-stage disease. Inappropriate HIV care includes drug therapy to prevent infections in low-risk patients, excessive laboratory monitoring, and long-term use of anti-retroviral drugs in patients with CD4 counts greater than 500.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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HIV and the primary care physician in Japan
Article Abstract:
Japan's health care system may be unable to care for large numbers of AIDS patients. Many Japanese physicians believe that AIDS is largely a Western phenomenon. Surveys have shown that many Japanese physicians do not want to treat HIV patients and many hospitals are not equipped to handle them. Japan also emphasizes hospital care rather than outpatient care. Japan has no formal informed consent guidelines and patients' civil rights are not well developed. All this will have to change if Japan is to deal successfully with the AIDS epidemic.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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