Hormone Replacement Therapy and Prevention of Nonvertebral Fractures: A Meta-analysis of Randomized Trials
Article Abstract:
Hormone replacement therapy may lower a woman's risk of hip fracture, according to a review of 22 clinical trials. However, this beneficial effect was seen predominantly in women under the age of 60.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Prevention of nonvertebral fractures by alendronate: a meta-analysis
Article Abstract:
The drug alendronate may reduce the risk of bone fractures in postmenopausal women with osteoporosis. Researchers tested the drug on 1,102 postmenopausal women with osteoporosis, while 590 similar women took a placebo. After three years, 9% of the women taking alendronate had fractured a bone at a site other than the spine, compared to 12.6% of the women in the placebo group. Alendronate reduced the risk of bone fractures by about 30%. Osteoporosis causes 1.5 million fractures in the US each year and this number may increase as the population ages.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Effects of Risedronate Treatment on Vertebral and Nonvertebral Fractures in Women With Postmenopausal Osteoporosis: A Randomized Controlled Trial
Article Abstract:
The bisphosphonate drug risedronate appears to be effective in reducing the risk of bone fracture in postmenopausal women with osteoporosis. Researchers randomly assigned 2,458 postmenopausal women with at least one previous bone fracture to take risedronate or a placebo for up to 3 years. Over the 3-year period, the drug reduced the rate of spinal fractures by 41% and the rate of other fractures by 39%. Bone density also increased in the women who took the drug compared to those who took a placebo.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial
- Abstracts: Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With Raloxifene: Results From a 3-Year Randomized Clinical Trial
- Abstracts: Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: A randomized controlled trial
- Abstracts: High-Density Lipoprotein Cholesterol and Ischemic Stroke in the Elderly: The Northern Manhattan Stroke Study. Preventing stroke among blacks: the challenges continue
- Abstracts: Mental health and health-related quality of life among adult Latino primary care patients living in the United States with previous exposure to political violence