Effects of cyclosporine therapy on plasma lipoprotein levels

Article Abstract:

Accelerated atherosclerosis, a leading cause of death for long-term survivors of heart and kidney transplant operations, may be aggravated by elevated lipid levels in the blood after transplantation. The dramatic changes in nutrition and metabolism that occur after transplantation and the many drugs transplant patients are given have made it difficult to discover the mechanism behind the high lipid levels in post-transplant patients. A double-blind study of the effects of cyclosporine, an immunosuppressive, on 36 men with amyotropic lateral sclerosis which lead to muscle weakening on one side of the body was conducted. The men treated with cyclosporine experienced a 21 percent increase in total blood cholesterol and significant increases in related substances. The results demonstrate that cyclosporine alone raises blood lipid levels.

Causes of, Complications and side effects, Physiological aspects, Heart, Kidneys, Kidney transplantation, Transplantation of organs, tissues, etc., Organ transplantation, Tissue transplantation, Transplantation, Heart transplantation, Cyclosporine, Cyclosporins

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The prevalence of high blood cholesterol levels among adults in the United States

Article Abstract:

It is estimated that 41 percent of adults should undergo evaluation of blood levels of lipoproteins after evaluation of blood cholesterol levels based on guidelines established by the National Cholesterol Education Program and data from the second National Health and Nutrition Examination Survey. It is predicted that 88 percent of the people needing lipoprotein analysis will need medical advice and attention to correct a high blood cholesterol level. This amounts to 40 million Americans between the ages of 20 and 59 years. An additional 24 million Americans over 60 years old may also need such advice and attention, although a less intensive approach to treatment may be appropriate for elderly patients.

Health aspects, Prevention, Americans

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Pharmacotherapy for Obesity

Article Abstract:

Drug therapy for obesity should be one of many methods for reducing the frequency of obesity in the US population. A 1999 study found that the drug orlistat was moderately effective in promoting weight loss. This drug reduces the absorption of fat in the intestinal tract by about 30%. The drug also lowered cholesterol levels. However, many patients taking the drug dropped out of the study. They were also on a diet, and few studies have evaluated the effect of diet drugs alone. While drug therapy may be useful, more effort should be expended on preventing obesity.

Editorial, Evaluation, Product/Service Evaluation, Drug therapy, Obesity, Orlistat (Medication)

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