Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria

Article Abstract:

Iron chelation therapy may increase the rate of recovery from a coma in children with cerebral malaria. Iron chelation therapy involves treatment with the drug deferoxamine. Among 83 children under six years old in a coma caused by cerebral malaria, 42 were treated intravenously with 100 milligrams of deferoxamine per kilogram of body weight per day and 41 received a placebo, or an inactive substance. Children treated with deferoxamine recovered full consciousness within an average of 20 hours, compared with an average of 43 hours for the children who received a placebo. Seventeen percent of the children treated with deferoxamine died, compared with 22% of those treated with a placebo. Among the 50 children in a deep coma, those in the deferoxamine group recovered twice as fast as those in the placebo group. Clearance of the malaria parasite was two times as fast in the children treated with deferoxamine compared with those treated with a placebo.

Care and treatment, Usage, Coma, Coma (Medicine), Deferoxamine

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Tumor necrosis factor and disease severity in children with falciparum malaria

Article Abstract:

In African children with a certain kind of malaria (falciparum malaria), the more of a certain bodily substance that kills tumors (tumor necrosis factor) they had in their blood, the more likely they were to die of this malaria. These children also had low blood sugar, tended to be under three years of age, had the most severe malaria and tended to die sooner after admission to the hospital. All patients had normal amounts of tumor necrosis factor in the fluid which surrounds the brain and spinal cord. When patients recovered from malaria, their levels of the substance declined.

Analysis, Case studies, Tumor necrosis factor, Plasmodium falciparum, Blood chemical analysis, blood

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Severe anemia in Malawian children

Article Abstract:

A study to ascertain if severe anemia was a major cause of sickness and death in African children especially in Malawi is conducted. Results show that there appeared to be many causes of anemia in preschool Malawian children but lack of folate and iron were not the main causes.

United States, Health aspects, Patient outcomes, Anemia, Risk factors, Folic acid, Iron, Iron (Metal), Clinical report, Malawians

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