Expression of matrix metalloproteinase-3 in the rat cervix during pregnancy and in response to prostaglandin E2

Article Abstract:

The study evaluates the expression of matrix metalloproteinase-3 in the cervix during normal pregnancy and in response to prostaglandin E2 administration to determine how matrix metalloproteinase-3 expression correlates with changes in cervical tensile strength. Prostaglandin E2 induces the activation of matrix metalloproteinase-3 protein expression, which suggests that matrix metalloproteinase-3 gene transcription is not regulated by prostaglandin E2 but that rather there is another mechanism by which change is induced.

United States, Complications and side effects, Pregnancy, Complications of, Pregnancy complications, Matrix metalloproteinase inhibitors

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Effects of selective and nonselective PGE2 receptor agonists on cervical tensile strength and collagen organization and microstructure in the pregnant rat at term

Article Abstract:

The prostaglandin E2 (PGE2) receptors (EP1-EP4) involved in cervical ripening in the rat are determined and their activities are examined in relation to the changes in tensile strength and collagen microstructure. The changes in cervical collagen organization and microstructure were quantifiable and were correlated with the changes in tensile strength.

Research and Development in the Physical, Engineering, and Life Sciences, Product information, Research and Testing Services, Medical Research, Epilepsy & Muscle Disease R&D, Administration of Public Health Programs, Health Research Programs, Case studies, Testing, Animal experimentation, Cervix uteri, Medicine, Experimental

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Effects of selective and nonselective PGE2 receptor agonists on cervical tensile strength and collagen organization and microstructure in the pregnant rat at term

Article Abstract:

The prostaglandin E2 (PGE2) receptors (EP1-EP4) involved in cervical ripening in the rat are determined and their activities are examined in relation to the changes in tensile strength and collagen microstructure. The changes in cervical collagen organization and microstructure were quantifiable and were correlated with the changes in tensile strength.

Alabama, Health aspects, Causes of, Rats, Rattus

Similar abstracts:

• Abstracts: Effects of selected vasoconstrictor agonists on isolated omental artery from premenopausal nonpregnant women and from normal and preeclamptic pregnant women
• Abstracts: Prospective randomized clinical trial of inpatient cervical ripening with stepwise oral misoprostol vs vaginal misoprostol. part 2

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