Effects of transdermal nitroglycerin on impedance to flow in the uterine, umbilical, and fetal middle cerebral arteries in pregnancies complicated by preeclampsia and intrauterine growth retardation

Article Abstract:

A nitroglycerine patch may be beneficial in pregnant women who develop preeclampsia. Preeclampsia is characterized by hypertension during pregnancy and protein in the urine. Researchers treated 17 pregnant women with preeclampsia with a transdermal nitroglycerine patch. Nitroglycerine relaxes blood vessels. The women experienced a drop in blood pressure and also a drop in resistance to blood flow in the uterus. When the patch was removed, blood pressure and resistance returned to the levels seen before the patch was used.

Health aspects, Evaluation, Blood flow, Fetus, Drug therapy, Transdermal medication, Transdermal drug delivery systems, Fetal growth retardation, Preeclampsia, Uterus, Nitroglycerin, Uterine circulation

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Randomized comparison between orally and transdermally administered hormone replacement therapy regimens of long-term effects on 24-hour ambulatory blood pressure in postmenopausal women

Article Abstract:

Hormone therapy delivered through a skin patch may not have a consistently positive effect on blood pressure compared to oral hormone therapy. In a study of 73 postmenopausal women, both forms of hormone therapy lowered blood pressure, but only the oral form caused a long-term decrease that persisted for up to six months.

Hormone therapy, Dosage and administration, Blood pressure

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Orally and transdermally replaced estradiol improves endothelial function equally in middle-aged women after surgical menopause

Article Abstract:

Both oral and transdermal estrogen can relax blood vessels, according to a study of 43 women who had their ovaries and uterus removed before natural menopause. This may be one mechanism by which hormone replacement therapy may reduce the risk of heart disease.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Estrogen & Progestogen Preps, Endothelium, Estrogen, Estrogens, Blood vessels, Vasodilation

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