Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus

Article Abstract:

The drugs metformin and troglitazone appear to be effective in lowering blood sugar levels in patients with non-insulin-dependent, or type 2, diabetes. Twenty-nine patients with type 2 diabetes were randomly assigned to take either drug for three months and then both drugs for another three months. Individually, both drugs lowered blood sugar levels by 20% to 25%. In combination, they lowered blood sugar another 18% to 21%. Metformin appears to work primarily by inhibiting blood sugar production, while troglitazone increases the rate of sugar metabolism.

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Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial

Article Abstract:

The drug troglitazone appears to be effective in lowering blood sugar levels in people with type 2, or adult-onset, diabetes. Researchers randomly assigned 93 people with type 2 diabetes to take various dosages of troglitazone or a placebo. The drug lowered blood sugar levels by about 20% at dosages of 400 or 600 milligrams per day. Most dosages also lowered blood insulin levels. The drug appeared to work by increasing the metabolism of blood sugar up to 45%.

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Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

Article Abstract:

Rosiglitazone, metformin, and glyburide were evaluated as initial treatment for type 2 diabetes diagnosed in a double blind, randomized, controlled clinical trial involving 4360 patients. The potential risks and benefits, the profile of adverse events and the costs of these three drugs should all be considered to help inform the choice of pharmacotherapy for patients with type 2 diabetes.

Diagnosis, Glibenclamide, Glyburide, Clinical report, Rosiglitazone maleate

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