Management of venous thromboembolism

Article Abstract:

Drug therapy can prevent serious consequences of deep-vein thrombosis and pulmonary embolism, which are blood clots in the legs and lungs, respectively. Following an accurate diagnosis, warfarin therapy should be started after an initial course of heparin. Low-molecular-weight heparins will replace unfractionated heparin in the near future. Long-term anticoagulant therapy needs to balance the risk of bleeding versus disease recurrence. Complications and drug side effects include bleeding, osteoporosis, skin necrosis, and painful swelling or ulcers in the legs. FDA-approved thrombolytic drugs include intravenous streptokinase and tissue plasminogen activator.

Health aspects, Anticoagulants (Medicine), Anticoagulants, Pulmonary embolism, Warfarin, Streptokinase

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Low-molecular-weight heparin in the treatment of patients with venous thromboembolism

Article Abstract:

Low-molecular-weight heparin appears to be as effective as regular heparin in the treatment of deep vein thrombosis. This condition is characterized by blood clots in the major leg veins that can travel to the lungs, causing pulmonary embolism. Of 1,021 patients with deep vein thrombosis, 510 were treated with injections of low-molecular-weight heparin and 511 received injections of regular heparin. One-third of the patients also had pulmonary embolism. The incidence of recurring blood clots was similar in both groups, as was the incidence of bleeding and death.

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Efects of a low-molecular-weight heparin on thrombus regression and recurrent thromboembolism in patients with deep vein thrombosis

Article Abstract:

Low-molecular-weight heparin is more effective in treating deep vein thrombosis than unfractionated heparin. Deep vein thrombosis occurs when a blood clot forms in the large veins of the leg. Low-molecular-weight heparin can be given as a subcutaneous injection whereas unfractionated heparin must be given intravenously.

Product/Service Evaluation, Clivarin (Medication)

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