Efficacy and safety of indomethacin compared with magnesium sulfate in the management of preterm labor: a randomized study

Article Abstract:

Indomethacin appears to be as effective as magnesium sulphate in suppressing premature labor. In a study of 101 patients who went into labor at <32 weeks gestation, 49 women received indomethacin and 52 received magnesium sulphate. Women were given a 100 milligram indomethacin rectal suppository to be followed by a 25 milligram oral dose every four hours for 48 hours. If the initial suppository was not effective in slowing the uterine contraction rate within one to two hours, another suppository was given. Magnesium sulphate was administered intravenously in an initial dose of six grams over 30 minutes. This was followed by administration of two grams per hour which was increased to up to five grams per hour if necessary. Delivery was delayed for at least 48 hours in 90% of the indomethacin group and 85% of the group receiving magnesium sulphate. Side effects were more common in the women receiving magnesium sulphate and eight of these women required discontinuation of the therapy. Because of concerns about fetal ductal constriction and depletion of amniotic fluid, fetal echocardiography and ultrasound monitoring of fluid volume should be considered.

Drug therapy, Premature labor, Magnesium sulfate

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Aggressive perinatal care for high-order multiple gestations: does good perinatal outcome justify aggressive assisted reproductive techniques?

Article Abstract:

It may not be necessary to reduce a triplet or quadruplet pregnancy to a twin pregnancy. In study of 53 women with a triplet or quadruplet pregnancy, prolonged hospitalization and early delivery were common, but otherwise the mother and baby did very well. Their outcomes were similar to women who had reduced and non-reduced twin pregnancies.

Pregnancy, Multiple, Multiple pregnancy

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A retrospective study of the effect of postoperative indomethacin rectal suppositories on the need for narcotic analgesia in patients who had a cesarean delivery while they were under regional anesthesia

Article Abstract:

A rectal suppository containing the painkiller indomethacin may reduce the need for narcotics in women who have had a cesarean delivery. This was the conclusion of a study of 297 women who had a cesarean at a community hospital.

Pregnant women, Rectum, Medication by, Rectal medication

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