Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer

Article Abstract:

Lumpectomy plus breast irradiation remains a recommended treatment for women with armpit nodes or tumors no larger than 4 centimeters in diameter. Researchers reanalyzed the data from a previous, multicenter clinical trial in which St. Luc Hospital was found to have falsified some patient records. The researchers performed three analyses: the first on all of the data, the second excluding data on St. Luc's women who refused the assigned treatment, and the third excluding all data from St. Luc's. The trial compared treatment with mastectomy, lumpectomy, and lumpectomy with breast irradiation. After 12 years, survival rates with each treatment were similar, regardless of which data set was analyzed. Survival without disease recurrence was also similar with each treatment according to each data set. However, tumor recurrence in the same breast occured in 35% of women who received only a lumpectomy, but in 10% of women who received a lumpectomy plus radiation therapy.

Mastectomy

---

Lumpectomy compared with lumpectomy and radiation therapy for the treatment of intraductal breast cancer

Article Abstract:

Radiation therapy may increase the chances of survival in women who have had a lumpectomy for intraductal breast cancer. A lumpectomy is a conservative type of surgery used to treat patients with localized breast cancer. Among 790 women with localized intraductal breast cancer who had a lumpectomy, 399 received radiation therapy and 391 did not. Eight-four percent of the patients who had radiation therapy were alive and disease-free after five years, compared with 74% of those who did not have radiation therapy. Radiation therapy decreased the risk of second ipsilateral breast cancer. Ipsilateral breast cancer is characterized by the development of a tumor in the same breast in which the original cancer occurred. Seven percent of the women who had radiation therapy developed ipsilateral breast cancer, compared with 16% of those who did not have radiation therapy.

---

Similar abstracts:

• Abstracts: The role of endothelium-derived hyperpolarizing factor in the regulation of the uterine circulation in pregnant rats
• Abstracts: Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor. Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study
• Abstracts: Epidemiologic and clinical features of HIV-infected and HIV-uninfected Ugandian children younger than 18 months. part 2
• Abstracts: A preliminary report of prenatal cocaine exposure and respiratory distress syndrome in premature infants. Growth, Development, and Behavior in Early Childhood Following Prenatal Cocaine Exposure: A Systematic Review
• Abstracts: A 16-year-old boy with a lesion of the left frontal lobe. A 40-year-old man with headache, fever, rash, and thrombocytopenia after a caribbean trip, case 40-1989

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.