Endothelin-1 release from cultured endothelial cells induced by sera from patients with systemic lupus erythematosus

Article Abstract:

Endothelin-1, a substance produced by endothelial cells, may cause damage to veins and arteries in people with systemic lupus erythematosus (SLE). Researchers studied the effect of blood from SLE patients on the release of endothelin-1 from endothelial cells in laboratory cultured human umbilical veins. Compared to the response of endothelial cells to blood from control subjects, endothelin-1 was released in much greater amounts in response to blood from SLE patients. The amount of endothelin-1 released in response to blood from SLE patients was associated with the amount of immunoglobulin M anti-endothelial cell antibodies and immune complex concentration. SLE patients experience kidney damage and high blood pressure in the lungs, and these may be caused by endothelin-1-induced vascular damage.

Injuries, Physiological aspects, Endothelin, Vascular endothelium

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Systemic lupus erythematosus (SLE) in childhood: analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults

Article Abstract:

People who develop systemic lupus erythematosus (SLE) in childhood more often have kidney disease, fever, and lymph gland disease than patients who develop the autoimmune condition as adults. Researchers compared 34 childhood-onset SLE patients and 396 adult-onset SLE patients. Childhood-onset SLE developed at an average age of 11 years, compared to 32 years in adult-onset patients. Autoantibodies were similarly prevalent in both groups, but childhood-onset patients were more likely to have immunoglobulin G anticardiolipin antibodies.

Demographic aspects, Anticardiolipin antibodies

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Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia

Article Abstract:

In finding a way to quantify the extent and severity of systemic lupus erythematosus (SLE), examination and measurement of the percentage of apoptotic or cell-killing peripheral blood neutrophils is a useful device, especially in establishing connections to neutropenia, or seriously diminished number of neutrophils in the blood. An increased number of circulating apoptotic neutrophils in SLE is a relatively certain indicator of disease progression and may contribute to its increase at the same time.

Measurement, Cell death, Neutrophils

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