Focal modification of electrical conduction in the heart by viral gene transfer
Article Abstract:
Research indicates that utilizing myocardial gene transfer strategies is a feasible approach to treat common cardiac arrhythmias. Findings were based on genetically modifying the atrioventricular node via infection with an adenovirus which created a localized beta-blockade and effectively slowed heart rate without resulting in a complete heart block.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
Article Abstract:
A study in which large, force-generating engineered heart tissue was created from neonatal rat heart cells was conducted. The engineered heart tissues formed thick cardiac muscle layers when implanted on myocardial infracts in immune-suppressed rats and provide evidence that large contractile cardiac tissue grafts could be constructed in vitro and survive after implantation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Molecular ablation of ventricular tachycardia after myocardial infarction
Article Abstract:
Focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border destroyed all ventricular arrhythmias in a porcine model. Results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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