Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli
Article Abstract:
Uropathogenic Escherichia coli may use complement component C3 as a host to invade the renal epithelium, with local complement production sufficient for this method. Renal epithelial cells have been seen to internalize fewer bacteria when C3 is not present, and upregulation of C3 enhances bacterial internalization.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade
Article Abstract:
Research indicates that CD40L antibodies deplete the activated T cells, instead of exerting immune modulation via costimulation blockade as currently understood. Data suggest that new treatments for immune disorders can be designed based on selective targeting of activated T cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells
Article Abstract:
This study conducted on uropathogenic Escherichia coli infected mice, shows that when they were administered with a cyclic AMP drug, the number of intracellular Escherichia coli decreased.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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