Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease: A Randomized Controlled Trial
Article Abstract:
Estrogen replacement therapy does not appear to be beneificial in women with mild to moderate Alzheimer's disease. Researchers randomly assigned 97 women with mild to moderate Alzheimer's disease to take estrogen or a placebo for up to 15 months. The women were tested periodically in areas such as mood, memory, attention, language skills, function, and activities of daily living. There was no difference in any of these tests between the women taking estrogen and those taking placebo. More research is needed to determine whether estrogen can prevent Alzheimer's disease in women.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial
Article Abstract:
Non-steroidal anti-inflammatory drugs (NSAIDs) may not slow the progression of Alzheimer's disease, according to a study of 351 patients. The drugs also had serious side effects, including gastrointestinal bleeding, stroke, and heart attack. This study was started because research has shown that chronic inflammation in the brain may cause Alzheimer's disease.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Vitamin E and donepezil for the treatment of mild cognitive impairment
Article Abstract:
Subjects were randomly assigned to receive 2000 IU of vitamin E daily, 10 mg of donepezil daily or placebo for three years and were evaluated with the amnestic subtype of mild cognitive impairment. The findings indicate that vitamin E had no benefit in patients with mild cognitive impairment and the rate of progression to Alzheimer's disease after three years was not lower among patients treated with donepezil than among those given placebo.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Impact of Disseminating Quality Improvement Programs for Depression in Managed Primary Care: A Randomized Controlled Trial
- Abstracts: Treatment of Acute Hypoxemic Nonhypercapnic Respiratory Insufficiency With Continuous Positive Airway Pressure Delivered by a Face Mask: A Randomized Controlled Trial
- Abstracts: Effects of Exercise Training on Left Ventricular Function and Peripheral Resistance in Patients With Chronic Heart Failure: A Randomized Trial
- Abstracts: Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection
- Abstracts: Congress wants alternative therapies studied; NIH responds with programs. New Center Director States "Complementary" Agenda