Evolution of pregnancies and initial follow-up of newborns delivered after intracytoplasmic sperm injection

Article Abstract:

Infants who are conceived using intracytoplasmic sperm injection (ICSI) appear to have no greater risk of birth defects than those conceived via in vitro fertilization (IVF). ICSI involves injecting a mature egg with sperm and can be used with dysfunctional sperm. Researchers followed the outcome of pregnancy in 751 couples who conceived via ICSI. The overall rate of pregnancy was 44.3% and the overall delivery rate was 38.7% per ICSI cycle. Only 2.6% of the 578 infants delivered had a major or minor birth defect, which is lower than the rate of birth defects in IVF infants.

Health aspects, Evaluation, Causes of, Birth defects, Human reproductive technology

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Paternity by intrauterine insemination with sperm from a man with 5-alpha-reductase-2 deficiency

Article Abstract:

Men who are born with 5-alpha-reductase-2 deficiency may still father children through artificial insemination. 5-alpha-reductase-2 is the enzyme that converts testosterone to its active metabolites. Male infants with the deficiency usually have ambiguous genitalia and may be raised as girls. They often develop male sexual features at puberty, but many are infertile. One man with this deficiency wished to have children. His semen was injected into his wife's uterus through a catheter. This technique resulted in three children.

Methods, Hermaphroditism, Paternity

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Births after intracytoplasmic injection of sperm obtained by testicular extraction from men with nonmosaic Klinefelter's syndrome

Article Abstract:

Doctors report the use of testicular extraction and intracytoplasmic injection to produce pregnancies in two couples with genetic male infertility. In both cases, the male partners had Klinefelter's syndrome, a genetic disorder that causes small reproductive organs and scant sperm production. Healthy sperm were extracted from testicular tissue obtained by biopsy, then injected into ova harvested from the female partners. Both procedures produced successful pregnancies and the birth of healthy children.

Abnormalities, Fertilization in vitro, Human, Human fertilization in vitro, Spermatogenesis, Klinefelter's syndrome, Klinefelter syndrome

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