Amniotic fluid interleukin-10 concentrations increase through pregnancy and are elevated in patients with preterm labor associated with intrauterine infection

Article Abstract:

Pregnant women experiencing preterm labor and infection within the uterus may have elevated levels of interleukin-10 in the amniotic fluid, signifying an attempt by the body to prevent preterm labor. Interleukin-10 is a protein messenger of the immune system that prevents inflammation resulting from infection. Intrauterine infection in pregnant women may produce inflammation that triggers preterm labor. Researchers measured the levels of interleukin-10 in amniotic fluid samples from 147 women obtained throughout their pregnancies. Interleukin-10 was detected in most fluid samples. The highest levels of interleukin-10 were found in women experiencing preterm labor and an intrauterine infection, compared to women with preterm labor but no infection or to women with term pregnancies but no labor.

Analysis, Risk factors, Interleukins, Premature labor, Amniotic fluid

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Maternal serum interleukin-6 concentrations in patients with preterm premature rupture of membranes and evidence of infection

Article Abstract:

Maternal blood levels of interleukin-6 may help identify which women with premature rupture of membranes have an impending uterine infection. Interleukin-6 plays a role in the inflammatory response. Blood samples taken from 110 women between 22 and 34 weeks gestation revealed that elevated interleukin-6 levels identified 96% of women with infection on the day of delivery while normal levels ruled out infection in 95% of cases. Levels began to rise one to two days before symptoms appeared, suggesting that a rise in interleukin-6 indicates incipient infection. This knowledge could help doctors decide whether to proceed with delivery.

Infection, Complications and side effects, Premature rupture of membranes, Premature rupture of the membrane, Uterus, Interleukin-6

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Characterization of progesterone receptor isoform expression in fetal membranes

Article Abstract:

A study aims to quantify the expression of progesterone receptor (PR) messenger RNA (mRNA) isoforms in fetal membranes, and to determine whether these levels change in culture. Quantitative reverse transcription polymerase chain reaction (QPCR) technology is used to quantitate PR mRNA isoform expression in fetal membranes, and to validate systems for further study of PR with respect to inflammation, infection and preterm delivery.

United States, Genetic aspects, Fetal membranes, Progesterone, Progesterone receptors

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