Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis

Article Abstract:

Studies conducted to evaluate the pathophysiological consequences of febrile seizures show that hyperthermia causes respiratory alkalosis in the immature brain with a threshold of 0.2 to 0.3 pH units for seizure induction. The effect of hyperthermia were closely mimicked by intraperitoneal injection of bicarbonate and the observation indicates a mechanism for triggering hyperthermic seizures, suggesting new strategies in the research and therapy of fever-related epileptic syndromes.

Health aspects, Causes of, Risk factors, Alkalosis

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Inhibition of respiratory viruses by nasally administered siRNA

Article Abstract:

Individual as well as joint infection by respiratory synyctial virus (RSV) and parainfluenza virus (PIV) can be specifically prevented using RNA interference (RNAi) and inhibited by short interfering (siRNAs), instilled intranasally in the mouse, with or without transfection reagents. The results suggest that, if properly designed, low dosages of siRNA might offer a fast, potent and easily administrable antiviral regimen against respiratory viral diseases in humans.

Usage, Prevention, Respiratory syncytial virus infection, Parainfluenza viruses, RNA interference

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Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits

Article Abstract:

Febrile seizures in immature rats leads to increased GABA inhibition that persists into adulthood. This indicates that febrile seizures in humans may not necessarily be benign.

Physiological aspects, GABA, Excitation (Physiology)

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