Experimentally induced intrauterine infection causes fetal brain white matter lesions in rabbits

Article Abstract:

It appears that some uterine infections can lead to fetal brain damage in experimental animals similar to that seen in many infants with cerebral palsy. Brain damage was assessed in the fetuses of 31 female rabbits injected with Escherichia coli at the cervix and 14 injected with saline (control group). Ten of the infected rabbits produced 12 fetuses with white matter brain damage. None of the control group produced fetuses with brain damage.

Models, Infection, Causes of, Complications and side effects, Cerebral palsy, Uterus, Chorioamnionitis, Brain damage

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The nuclear transcription factor NF-kappaB mediates interleuking-1beta-induced expression of cyclooxygenase-2 in human myometrial cells

Article Abstract:

Nuclear transcription factor NF-kappaB appears to be an intermediary in the production of cyclooxygenase-2 (COX-2) in the uterus. COX-2 in turn stimulates the production of prostaglandins. This process begins when an infection stimulates interleukin-1beta which stimulates the production of NF-kappaB. The end result is premature labor.

Physiological aspects, Premature labor, Interleukin-1

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Bacterial vaginosis, the inflammatory response and the risk of preterm birth: a role for genetic epidemiology in the prevention of preterm birth

Article Abstract:

The concepts of bacterial vaginosis, vaginal inflammation, the importance of genetic control of the inflammatory response are discussed in the context of microbial invasion, and the significance of the report of Dr Macones. It is reported that a gene-environment interaction determines risk for preterm birth.

Science & research, Health aspects, Risk factors, Infants (Premature), Premature infants, Vaginosis, Genetic research, Bacterial vaginosis

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