Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

Article Abstract:

Estradiol (E2) is shown to trigger an increase in the number of excitatory inputs to prooplomelanocortin (POMC) neurons in the arcuate nucleus of wild-type rats and mice. The results have shown that synaptic plasticity of arcuate nucleus feeding circuits is an inherent element in body weight regulation and has provided alternative approaches to reducing adiposity under conditions of failed leptin receptor signaling.

Estradiol, Fat cells, Adipocytes

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Big deal about a little insulin

Article Abstract:

The identification of an orally active, small molecule insulin mimic, L-783,281, has led to new opportunities for therapy for diabetes. Whether or not L-783,281, or variants, will be active in patients with either type of diabetes is not yet known, but there are some precedents for small molecule agonists of tyrosine kinase receptors, or receptors that activate associated tyrosine kinases of the Jak family.

Drug therapy, Diabetes, Diabetes mellitus, Insulin

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Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

Article Abstract:

A study to determine the functional significance of suppressor of cytokine signaling-3 (Socs3) in energy balance, with the help of heterozygous Socs3 deficient mice, is presented. The results reveal that level of Socs3 expression is a critical determinant of leptin sensitivity and obesity susceptibility and this molecule is a potential target for therapeutic intervention.

Heterozygosis, Heterozygote, Cytokine receptors

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