Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: Correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival

Article Abstract:

The relationship between cyclo-oxygenase-2 expression and tumor proliferation, apoptosis and angiogenesis is examined in patients with advanced stage high-grade ovarian carcinoma. In high-grade, advanced-stage serous ovarian carcinoma, the expression of cyclo-oxygenase-2 was found to be correlated with tumor proliferation and tumor angiogenesis but was not correlated with apoptotic markers.

Michigan, Health aspects, Patient outcomes, Ovarian cancer, Cancer patients, Neovascularization

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Gene therapy of uterine leiomyomas: Adenovirus-mediated expression of dominant negative estrogen receptor inhibits tumor growth in nude mice

Article Abstract:

A potential therapy for leiomyomas (fibroids) is investigated where a mutated dominant-negative estrogen receptor gene delivered via an adenoviral vector was used. The study concludes that dominant-negative estrogen receptor gene therapy may provide a non-surgical treatment option for women with symptomatic uterine fibroids who want to preserve their uteri.

United States, Gene therapy, Dosage and administration, Adenoviruses

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The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas

Article Abstract:

The effects of the chemopreventive agents 4-(N-hydroxyphenyl)-retinamide (4-HPR) and alpha-difluromethylornithine (DFMO) on leiomyoma growth are examined. The treatment with chemopreventive agents 4-HPR and DFMO induces apoptosis and inhibits the growth of primary cultures of human uterine leimyomas in vitro.b

Chemoprevention, Difluoromethylornithine

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