External alkalinization decreases intracellular Ca++ and spontaneous contractions in pregnant rat myometrium

Article Abstract:

Calcium ion (Ca++) regulation appears to play a role in the decreased contraction response seen with an increased, or more basic, pH. Contractile force, pH, and Ca++ levels were measured in stimulated uterine wall muscle fibers from rats. A more basic pH environment decreased both the contractile response and Ca++ levels. Contraction response increased after treatment with a Ca++ stimulator.

Myometrium

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The effects of pH change on Ca++ signaling and force in pregnant human myometrium

Article Abstract:

Increased acidity in the uterus can inhibit contraction, most likely by reducing calcium in the uterus. The uterus can become more acidic if a contraction is strong enough to block the flow of blood to the uterus. This has been demonstrated in rats but this study used strips of uterine tissue taken from women who had a cesarean delivery.

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Intracellular calcium stores and agonist-induced contractions in isolated human myometrium

Article Abstract:

Uterine contractions may involve an increase in calcium levels inside cells, according to a study of uterine tissue samples taken from 48 women. Muscle contraction normally occurs when calcium outside the cell enters the cell. This study shows that calcium inside the cell also plays a role in muscle contraction.

Analysis

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