Characterization of large-conductance, calcium-activated potassium channels from human myometrium
Article Abstract:
The muscular wall of the uterus (myometrium) may have two types of potassium channels. These channels may cause the potassium currents involved in the initiation of uterine contractions. A study examined the different types of potassium channels in myometrium samples from premenopausal women who were not pregnant. The most common type of potassium channel was a 'maxi' calcium-activated potassium channel. This type of channel was sensitive to intracellular calcium and had a large conductance. It was similar to calcium-activated potassium channels found in other types of tissue and in other species. Several different types of drugs affected the activity of this type of channel. Another less common type of potassium channel was also found in the samples of myometrium. This channel was less sensitive to intracellular calcium and had lower conductance.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1993
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Expression of different potassium channels in cells isolated from human myometrium and leiomyomas
Article Abstract:
The electrical properties of myometrial and leiomyoma cells may be different. The myometrium is the smooth muscle coat of the uterus. A leiomyoma is a benign tumor derived from the myometrium. A study examined the different types of potassium channel currents in myometrial and leiomyoma cells. Three types of potassium channel currents were found in myometrial cells. These included two types of noninactivating outward currents and one type of inactivating current. Leiomyoma cells were more likely to have fast outward inactivating potassium channel currents. Different types of complications caused by leiomyomas include infertility and abnormal uterine bleeding.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1993
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The expression of integrins and cadherins in normal human uterus and uterine leiomyomas
Article Abstract:
Two molecules responsible for cell adhesion called cadherin and integrin seem to be expressed in a similar pattern in normal uterine tissue and in leiomyomas. Leiomyomas are a common nonmalignant uterine tumor. Researchers compared cadherin and integrin patterns in tissue samples taken from normal uterine lining, normal uterine muscle, and leiomyoma. Cadherin and integrin patterns were similar in all tissue samples. These patterns changed in the uterine lining cells during the menstrual cycle but remained constant in the uterine muscle and leiomyoma cells.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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