Extravasation of iopamidol and iohexol during contrast-enhanced CT: report of 28 cases
Article Abstract:
Contrast media are chemicals given to patients, usually by injection into the veins, that enhance images of tissues and organs being examined for diagnostic or treatment purposes. There are two general categories of contrast media, ionic and nonionic. Both types can cause various side effects. Nonionic media are much more expensive than ionic media, but are thought to cause fewer and less severe side effects. One possible side effect of either media type is tissue damage, which occurs when the media leaks or is inadvertently injected outside of a blood vessel (extravasation). This study examined the incidence and severity of this side effect when nonionic media was used. During a 27-month period, only nonionic contrast media, iopamidol and iohexol, were used with computed tomography (CT) scanning in one radiology department. During this period, 28 cases of extravasation occurred during injection of contrast material. The extravasated volume was recorded for 19 cases. The amount of extravasated material was considered major in seven cases, moderate in nine cases, and minor in three cases. None of the patients experienced damage to the tissue at the site of injection and the only treatment required for all patients was application of a compress. Pain and swelling at the site lasted two-to-four days in most patients, and for more than one week in only one patient. The rate of extravasation varied somewhat with the area of the body being examined. For neurologic examination, the rate was 0.09 percent; for examination of other areas of the body, it was 0.14 percent. These results indicate that when extravasation occurs during the injection of contrast media, nonionic media are much less likely to cause tissue damage than ionic contrast media. This is an additional consideration to be weighed when balancing the costs, benefits, and risks of using various types of contrast media. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Radiology
Subject: Health
ISSN: 0033-8419
Year: 1991
User Contributions:
Comment about this article or add new information about this topic:
The long-term clinical course of acute deep venous thrombosis
Article Abstract:
Patients who have experienced deep venous clots appear likely to experience recurrent clots or other symptoms of blocked circulation over the long term. Of 355 patients experiencing a deep venous clot in a leg, 30% experienced another leg vein clot and 30% experienced venous ulceration, severe pain, or intractable swelling within a follow-up period of eight years. Having cancer or a disease that increased the risk of blood clots increased the risk of having recurrent clots or other venous symptoms and experiencing the first clot as a result of surgery or other injury reduced the risk.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Evaluation of social security disability in claimants with rheumatic disease. The carpal tunnel syndrome: diagnostic utility of the history and physical examination findings
- Abstracts: A controlled trial of castration with and without nilutamide in metastatic prostatic carcinoma. Introduction to the Workshop on Combined Castration and Androgen Blockade Therapy in Prostate Cancer
- Abstracts: A comparison of adenocarcinoma and squamous cell carcinoma of the cervix. Exercise and incontinence
- Abstracts: A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor. Prenatal administration of indomethacin as a tocolytic agent: effect on neonatal renal function
- Abstracts: Sonographic determination of tubal rupture in patients with ectopic pregnancy: is it feasible? Can the status of tubal pregnancy be predicted with transvaginal sonography? A prospective comparison of sonographic, surgical, and serum hCG findings