Fasting hypoketotic coma in a child with deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase

Article Abstract:

Children who become comatose after fasting should be suspected of having a defect in the mitochondrial enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase. This liver enzyme converts fatty acids into chemicals called ketones, which the body can use as fuel if glucose is unavailable. An 11-year-old boy had a history of coma whenever he went for a few days without food. Blood tests during a fasting state revealed that his glucose levels dropped but his ketone levels were far below normal. He became comatose but recovered after receiving intravenous glucose. Analysis of liver tissue samples revealed that the activity of the enzyme was 10% of normal.

Health aspects, Measurement, Causes of, Physiological aspects, Coma, Coma (Medicine), Fasting, Ketones, Hydroxymethylglutaryl coenzyme A reductases

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Straight from the shoulder

Article Abstract:

An implantable device for storing the medical identifier of a patient is available and can be implanted in the posterior aspect of the arm between the elbow and the shoulder. When a scanner is passed within 15 cm of the person's arm, the medical identifier of the person is displayed on the screen of a radio frequency identification (RFID).

United Kingdom, Search, Detection, Navigation, Guidance, Aeronautical, and Nautical System and Instrument Manufacturing, Radio & TV communications equipment, Radio Frequency Detector Eqp, Usage, Implants, Artificial, Prostheses and implants, Prosthesis, RFID equipment, Radio frequency identification (RFID), Radio frequency identification

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