Functional engraftment of human ES cell-derived dopaminergic neuron enriched by coculture with telomerase-immortalized midbrain astrocytes
Article Abstract:
A new strategy for improving the efficiency of dopaminergic neurogenesis from human embryonic stem (HES)-cell cultures is discussed by using coculture with telomerase-immortalized human fetal mesencephalic astrocytes at the time of sonic hedgehog + fibroblast growth factor-mediated neuronal induction. Results show the utility of recreating the cellular environment of the developing human midbrain when driving dopaminergic neurogenesis from HES cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral aclerosis
Article Abstract:
Research has been conducted on creatine administration. Results indicate that oral administration of creatine improves motor performance, extends survival in transgenic mice and protects mice from motor neuron and nigra neuron loss and that creatine administration can become a therapeutics for amyotrophic lateral aclerosis treatment.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain
Article Abstract:
Late-gestation and adult human forebrain, both contain large numbers of oligodendrocyte progenitor cells (OPCs). Adult OPCs generated oligodendrocytes more efficiently than fetal OPCs and ensheathed more host axons per donor cell than fetal cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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